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  1. Schizophrenia with onset at the extremes of adult life.

    Article - En anglais

    Objective

    To define the epidemiology, phenomenology, premorbid and risk factors in patients with the first manifestation of a schizophrenia-like illness after the age of 60 years, and compare them with patients with an onset before the age of 25 years.

    Design/setting/subjects

    All contacts for a non-affective psychotic illness across all ages of onset were ascertained through a psychiatric case register ; patients were rediagnosed according to operationalized criteria for psychotic illness, and those with a very early and very late onset compared.

    Main outcomes measures

    Phenomenological, premorbid and aetiological parameters were compared in the two groups, using risk ratios and 95% confidence intervals.

    Results

    Very late onset patients (N=72) were, compared to their very early onset counterparts (N=192), more likely to be female, have good premorbid functioning and developmental history, and to exhibit persecutory delusions and hallucinations ; they were less likely to have negative schizophrenic symptoms, to have a positive family history of schizophrenia, or have suffered pregnancy or birth complications.

    Conclusions

    The results highlight premorbid, aetiological and phenomenological differences between patients with the onset of a schizophrenia-like illness at the extremes of adult life, and suggest it is premature to consider the two groups to be merely different manifestations of the same illness.

    Mots-clés Pascal : Schizophrénie, Psychose, Age apparition, Tardif, Etiologie, Paraphrénie, Facteur risque, Antécédent, Epidémiologie, Phénoménologie, Sexe, Vieillard, Homme

    Mots-clés Pascal anglais : Schizophrenia, Psychosis, Age of onset, Late, Etiology, Paraphrenia, Risk factor, Antecedent, Epidemiology, Phenomenology, Sex, Elderly, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0407989

    Code Inist : 002B18E. Création : 19/12/1997.