Traduction en anglais : High percentage of isolated anti-HBc-positive persons among prisoners.
higher among prisoners than in the normal population and can testing for HBV-DNA clarify the results ?
In Berlin, 519 prisoners were serologically tested in 1994 for hepatitis-B and - C because of intravenous drug abuse and alcohol disease or signs of hepatitis.
Beside virus antigen and antibodies, HBV-DNA was also measured by hybridisation technique or PCR.
50.3% of all individuals showed markers of hepatitis-B and 36.8% of hepatitis-C. 19.2% of persons with hepatitis B markers were positive for anti-HBc only, i.e. more than twice as many than in the normal population. 90% of the isolated anti-HBc-positive Persons were also anti-HCV positive, which is nearly double the number of individuals with other patterns of HBV markers.
Half of them were tested for HBV-DNA.
Whereas the hybridisation technique failed to detect HBV-DNA, 36% of sera were found positive by HBV-PCR.
This study shows again that the result « anti-HBc alone » is relatively frequent especially among prisoners.
This pattern often seems associated with concurrent HCV-infection and in one third of the cases correlated with a chronic hepatitis-B.
The result of an isolated anti-HBc should therefore always lead to further testing of anti-HCV and HBV-DNA by PCR.
Mots-clés Pascal : Milieu carcéral, Homme, Hépatite virale B, Virose, Infection, Prévalence, Sérologie, Séropositivité, Epidémiologie, Allemagne, Europe, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Carceral environment, Human, Viral hepatitis B, Viral disease, Infection, Prevalence, Serology, Seropositivity, Epidemiology, Germany, Europe, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0406906
Code Inist : 002B05C02G. Création : 19/12/1997.