It has been suggested that the threshold limit value (TLV) for the time-weighted average (TWA), of benzene be lowered because of its possible leukemogenic effect at low exposure concentrations.
This requires the development of new methods of biological monitoring.
In this cross-sectional study the diagnostic power of blood and breath benzene and of urinary phenol, catechol, hydroquinone, S-phenylmercapturic acid, and muconic acid were compared in a population of 410 male workers exposed to benzene in garages, in two coke plants, and in a by-product plant.
Benzene exposure was assessed by personal air sampling (charcoal tube and passive dosimeter).
In all, 95% of the workers were exposed to less than 0.5 ppm benzene.
According to the multiple regression equation, the muconic acid and S-phenylmercapturic acid concentrations detected in nonsmokers exposed to 0.5 ppm benzene were 0.3 mg/g and 6 mug/g, respectively (range 0.2-0.6mg/g and 1.2-8.5 mug/g, respectively).
With muconic acid very few false-positive test results were found, and this determination remained reliable even around a cutoff level of 0.1 ppm benzene.
Moreover, the diagnostic power of this test proved to be good even when diluted or concentrated urine samples were not excluded.
S-Phenylmercapturic acid (S-PMA) also performed fairly well.
Blood and breath benzene as well as urinary phenol (PH) and hydroquinone (HQ) were clearly less suitable biomarkers than muconic acid (MA). (...)
Mots-clés Pascal : Benzène, Exposition professionnelle, Médecine travail, Toxicité, Homme, Industrie, Garage commercial, Concentration maximale admissible, Révision, Surveillance biologique, Marqueur biologique, Urine, Liquide biologique, Dose faible
Mots-clés Pascal anglais : Benzene, Occupational exposure, Occupational medicine, Toxicity, Human, Industry, Commercial garage, Maximum permissible concentration, Revision, Biological monitoring, Biological marker, Urine, Biological fluid, Low dose
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0405474
Code Inist : 002B03L06. Création : 19/12/1997.