Elevated serum liver enzymes in coke oven and by-product workers.
Coke oven and by-product workers are potentially exposed to coke oven emissions (COE), which contain hundreds of chemicals and are primarily composed of polycyclic aromatic hydrocarbons (PAH) and volatile organic compounds.
Some of these compounds are hepatotoxins.
The objective of this study was to examine the relationship between work in coke oven and by-product plants and serum activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), the most commonly performed liver-function tests.
The exposed group was composed of current workers who had been employed at least 3 months in the two coke-operation work areas, including one coke oven plant and one by-product plant (Area I : n=117 ; Area II : n=96) of a large steel company in Taiwan.
Control subjects (Area III :
N=131), not visiting either coke-operation area in the last 3 months, were collected from the administrative and nonproduction areas in the same company.
PAH exposure, as a surrogate of COB, was measured monthly by PM-10 size-selective high-volume-area air samplers in or around these three areas between June and December 1990, as well as between November 1992 and June 1993.
The mean total respiratory particulate PAH exposure levels (<10 mum) between November 1992 and June 1993 in Areas I, II, and III were 6.8 X 103,2.1 X 103, and 6.5 X 101 ng/m3, respectively.
AST, ALT, and hepatitis B surface antigen tests were performed in 1994. (...)
Mots-clés Pascal : Four coke, Composé organique volatil, Composé aromatique polycyclique, Industrie charbonnière, Toxicité, Homme, Exposition professionnelle, Médecine travail, Foie pathologie, Marqueur biologique, Aspartate transaminase, Transaminases, Transferases, Enzyme, Alanine transaminase, Taiwan, Asie, Surveillance biologique, Appareil digestif pathologie
Mots-clés Pascal anglais : Coke oven, Volatile organic compound, Polycyclic aromatic compound, Coal industry, Toxicity, Human, Occupational exposure, Occupational medicine, Hepatic disease, Biological marker, Aspartate transaminase, Transaminases, Transferases, Enzyme, Alanine transaminase, Taiwan, Asia, Biological monitoring, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0405306
Code Inist : 002B03L02. Création : 19/12/1997.