Predictors of disease progression were studied in 89 asymptomatic HIV-infected patients who were prospectively evaluated for psychosocial variables and the development of clinical symptoms over a period of 2 years.
The subjects were assessed for symptoms, laboratory measures, demographic variables, social and personal resources, mental status, alcohol, nicotine and drug use, sexual activity and risk behaviour, and sexually transmitted diseases.
After 1 year, 17% of the patients had developed HIV-associated symptoms (symptomatic disease or AIDS), and after 2 years, 32% had developed symptoms or had died.
In the multivariate analyses, the baseline CD4 count was the only significant predictor of disease progression during both observation periods.
Psychosocial measures did not predict the progression of HIV infection.
Mots-clés Pascal : SIDA, Virose, Infection, Séropositivité, Facteur prédictif, Evolution, Comportement sexuel, Consommation, Boisson alcoolisée, Substance toxicomanogène, Réseau social, Coping, Démographie, Santé mentale, Prise risque, Maladie sexuellement transmissible, Epidémiologie, Marqueur biologique, Lymphocyte T, Homme, Immunopathologie, Immunodéficit, Antigène CD4, Antigène CD8, Antigene p24
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Seropositivity, Predictive factor, Evolution, Sexual behavior, Consumption, Alcoholic beverage, Drug of abuse, Social network, Coping, Demography, Mental health, Risk taking, Sexually transmitted disease, Epidemiology, Biological marker, T-Lymphocyte, Human, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0404005
Code Inist : 002B06D01. Création : 19/12/1997.