Data on household and dwelling contact with known leprosy cases were available on more than 80,000 initially disease-free individuals followed up during the 1980s in a rural district of northern Malawi.
A total of 331 new cases of leprosy were diagnosed among them.
Individuals recorded as living in household or dwelling contact with multibacillary patients at the start of follow-up were at approximately five-to eightfold increased risk of leprosy, respectively, compared with individuals not living in such households or dwellings.
Individuals living in household or dwelling contact with paucibacillary cases were both at approximately twofold increased risk.
The higher risk associated with multibacillary contact and the fact that dwelling contact entailed a greater risk than household contact if the association was with multibacillary, but not with paucibacillary, disease suggest that paucibacillary cases may not themselves be sources of transmission, but rather just markers that a household has had contact with some (outside) source of infection.
When household contact was considered alone, the risks of disease were appreciably higher for younger than for older contacts and for male compared with female contacts.
Despite the elevated risk of leprosy associated with household or dwelling contact, only 15% of all incidence cases arose among recognized household contacts. (...)
Mots-clés Pascal : Lèpre, Mycobactériose, Bactériose, Infection, Epidémiologie, Facteur risque, Transmission, Logement habitation, Milieu rural, Homme, Malawi, Afrique, Mycobacterium leprae, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bactérie, Peau pathologie
Mots-clés Pascal anglais : Leprosy, Mycobacterial infection, Bacteriosis, Infection, Epidemiology, Risk factor, Transmission, Housing, Rural environment, Human, Malawi, Africa, Mycobacterium leprae, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bacteria, Skin disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0402686
Code Inist : 002B05B02L1. Création : 19/12/1997.