The role of host and environmental factors in the pathogenesis of multiple melanocytic nevi, atypical nevi, and freckles was studied in 1989 in a random sample of 3,040 Israeli males aged 17 years.
Multiple melanocytic nevi were significantly associated with family history of melanoma or multiple melanocytic nevi (odds ratio (OR)=15.0), fair or lightly pigmented skin color (OR=2.7 and 2.3, respectively), and affiliation to the high or heterogenous melanoma risk group, determined by the incidence rates of melanoma in Jewish migrants from corresponding origin (OR=3.1 and 2.1, respectively).
An environment-related effect may account for the increased multiple melanocytic nevi risk among second- (OR=8.2) compared with first-generation, native-born recruits (OR=3.0) from the high melanoma risk group whose families had been living in Israel the longest.
Atypical nevi were associated with fair (OR=6.1) and lightly pigmented (OR=3.5) skin color, high and moderate sunburn susceptibility (OR=4.7 and 2.5, respectively), and family history of melanoma or multiple melanocytic nevi (OR=4.7).
Freckles were significantly associated with sun-sensitive phenotype, family history of melanoma or multiple melanocytic nevi (OR=1.5), Conservative (OR=1.9) or nonreligious status (OR=1.9), and high (OR=2.4) or heterogenous melanoma risk groups (OR=1.8). (...)
Mots-clés Pascal : Naevus naevocellulaire, Adolescent, Homme, Mâle, Israël, Asie, Epidémiologie, Mélanome, Juif, Immigrant, Déterminisme génétique, Lieu naissance, Soleil, Facteur risque, Peau pathologie, Tumeur, Ephélide
Mots-clés Pascal anglais : Melanocytic nevus, Adolescent, Human, Male, Israel, Asia, Epidemiology, Melanoma, Jew, Immigrant, Genetic inheritance, Birth place, Sun, Risk factor, Skin disease, Tumor, Freckle
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0402684
Code Inist : 002B08A. Création : 19/12/1997.