Fermeture du portail BDSP le 1er juillet 2019. En savoir plus...
-
Relation between birth weight and the insulin sensitivity index in a population sample of 331 young, healthy caucasians. 
AMERICAN JOURNAL OF EPIDEMIOLOGY, vol. 146, n° 1, 1997, pages 23-31, 50 réf., ISSN 0002-9262, USA
CLAUSEN (J.O.), BORCH-JOHNSEN (K.), PEDERSEN (O.)
Copenhagen County. Center of Preventive Medicine. Medical Department C. Glostrup University Hospital. Gentofte. DNK, Steno Diabetes Center. Gentofte. DNK
The objective was to study the association between birth weight and the insulin sensitivity index.
Altogether, 331 unrelated Caucasian subjects aged 18-32 years with measures of the insulin sensitivity index and insulin secretion during a combined intravenous glucose and tolbutamide tolerance test were included in the study.
The data on birth weight and length were obtained from the midwife records.
The study took place in Copenhagen, Denmark, during 1992-1993.
Univariately, a significant positive association between birth weight and the insulin sensitivity index was found in women (p=0.045), but not in men (p=0.23).
In multivariate analysis, controlling for age, gender, body mass index, waist circumference, maximal aerobic capacity, and use of oral contraceptives, no significant interaction between birth weight and gender that considered the insulin sensitivity index was found.
The insulin sensitivity index was significantly associated with birth weight (p=0.0012), corresponding to an increase of 1.7% (95% confidence interval 0.7-2.7%) in the insulin sensitivity index for each 100-g increase in birth weight.
In comparison, an increase in body mass index of 1 kg/m2 (a weight gain of 2.9 kg in a man 1.70 m tall) corresponds to a decrease in the insulin sensitivity index of 3.8% (95% confidence interval 0.7-6.8%), an increase in waist circumference of 1 cm corresponds to a decrease in the insulin sensitivity index of 2.1% (95% confidence interval 0.9-3.1 ;) (...)
Mots-clés BDSP : Poids naissance, Epidémiologie, Insuline, Sensibilité, Danemark, Europe, Anthropométrie, Sexe, Glucose, Jeune adulte, Homme
Mots-clés Pascal : Poids naissance, Epidémiologie, Insuline, Sensibilité, Hormone protéine, Danemark, Europe, Anthropométrie, Sexe, Glucose, Adulte jeune, Homme
Mots-clés Pascal anglais : Birth weight, Epidemiology, Insulin, Sensitivity, Protein hormone, Denmark, Europe, Anthropometry, Sex, Glucose, Young adult, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et TechniqueCote : 97-0402679
Code Inist : 002B20G01. Création : 19/12/1997.