This study evaluated post-treatment performance and quality of life (QOL) outcome in head and neck cancer (HNC) patients treated with organ preservation, intensive chemeradiotherapy (FHX).
Participants were 47 Stage II-IV HNC patients with no evidence of disease at least one year postcompletion of organ preservation, concomitant FHX treatment.
Patients were assessed via a semi-structured in-person interview, standardized measures of QOL (FACT-H & N, CES-D), performance (PSS-HN) and patients'perception of residual side effects.
Disease, treatment and toxicity data were retrieved from medical charts and protocol records.
The most salient performance impairment was inability to eat a normal solid food diet, with 50% of patients able to eat soft foods or take liquids only.
This specific functional deficit was not related to global QOL, nor to specific quality of life dimensions.
Dry mouth, the most frequent and severe residual effect, was not associated with outcome diet, depression or QOL.
Residual pain, seen in only 15% of patients, appeared to influence both functional and QOL parameters as well as being a marker for other troublesome symtoms.
Twenty-three per cent of patients were depressed ; depression was associated with past problems related to alcohol abuse.
Decreased QOL and increased depressive symptomatology were related to total number and severity of residual effects. (...)
Mots-clés Pascal : Chimiothérapie, Traitement, Anticancéreux, Médicament, Tumeur maligne, Tumeur, Maladie, Tête, Corps, Anatomie, Cou, Société, Sociologie, Survie, Epidémiologie, Variable, Performance, Evaluation, Méthodologie, Effet secondaire, Pharmacovigilance, Qualité vie, Mode de vie, Indicateur, Mortalité, Contrôle qualité, Prévention, Santé, Politique sanitaire, Mesure
Mots-clés Pascal anglais : Chemotherapy, Treatment, Antineoplastic agent, Drug, Malignant tumor, Tumor, Disease, Head, Body, Anatomy, Neck, Society, Sociology, Survival, Epidemiology, Variable, Performance, Evaluation, Methodology, Secondary effect, Pharmacovigilance, Quality of life, Life habit, Indicator, Mortality, Quality control, Prevention, Health, Health policy, Measurement
Notice produite par :
ORS Auvergne - Observatoire Régional de la Santé d'Auvergne
Code Inist : 002B30A11. Création : 16/10/1997.