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  1. Fulltext. Exogenous gangliosides and Guillain-Barré syndrome : An observational study in the Local Health District of Ferrara, Italy.

    Article - En anglais


    A retrospective study was carried out in the Ferrara Local Health District, Italy, for the period 1981-1993 (average resident population : 177 235 inhabitants) to establish whether people exposed to exogenous gangliosides had a higher risk of Guillain-Barré syndrome.

    The incidence of Guillain-Barré syndrome of 1.9/100 000 population/year [95% confidence interval (CI) : 1.3-2.5] reported in Ferrara Local Health District in the same period was used as a reference for comparison.

    The data bank of Ferrara Local Health District made it possible, first to estimate the number of individuals exposed to gangliosides in the resident population of Ferrara Local Health District (3.7%), the number of ganglioside prescriptions and the number of cases of Guillain-Barré syndrome who had treatment with gangliosides (nine patients, 20.9%), and, secondly, to verify the sequence of events between the ganglioside injection and the onset of the disease.

    Seven of the nine patients (77.8%) received gangliosides as treatment for peripheral neuropathy (Guillain-Barré syndrome onset before gangliosides were prescribed).

    For the other two patients (22.2%) a possible appropriate temporal sequence between ganglioside injection and onset of Guillain-Barré syndrome was found.

    Based on two possible ganglioside-related cases, the risk of Guillain-Barré syndrome was higher in the exposed (0.53/100 000 population/month following ganglioside injection, - 95% Cl : 0.06-1. (...)

    Mots-clés Pascal : Polyradiculonévrite Guillain Barré, Ganglioside, Exogène, Mélange, Italie, Europe, Risque, Traitement, Toxicité, Homme, Système nerveux pathologie, Nerf périphérique pathologie, Maladie inflammatoire, Chimiothérapie

    Mots-clés Pascal anglais : Guillain Barré syndrome, Ganglioside, Exogenous, Mixture, Italy, Europe, Risk, Treatment, Toxicity, Human, Nervous system diseases, Peripheral nerve disease, Inflammatory disease, Chemotherapy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0397701

    Code Inist : 002B02U01. Création : 12/09/1997. Dernière mise à jour : 12/08/2015.