To investigate the cause of sporadic motor neuron disease (MND) by twin study, so allowing (1) estimation of the genetic contribution, and (2) collection of matched pairs for a case-control study of possible environmental factors.
Methods--10 872 death certificates bearing the diagnosis MND were collected from 1979 to 1989 inclusive.
Inspection of individual birth entries allowed identification of potential twins.
The status of each co-twin was determined and contact made through the National Health Service Central Register (NHS-CR) and their general practitioner (GP).
The diagnosis of MND was verified via the co-twin and relatives, and medical records where available.
Zygosity was assessed using a recognised questionnaire.
Details concerning environmental exposures and health were gathered by interview of co-twin and relatives using a semistructured questionnaire.
Heritability (h2) of MND was estimated, and the environmental information was analysed by conditional logistic regression modelling.
Seventy seven probands were identified, of whom 26 were monozygotic and 51 dizygotic.
Four monozygotic probands were concordant, but two probands came from a family known to have familial MND.
The estimated heritability was between 038 and 085.
Most environmental risk factors were not significant. (...)
Mots-clés Pascal : Neurone moteur maladie, Sporadique, Jumeau, Royaume Uni, Europe, Facteur milieu, Paramètre génétique, Facteur risque, Etiologie, Homme, Système nerveux pathologie, Système nerveux central pathologie, Moelle épinière pathologie, Maladie dégénérative
Mots-clés Pascal anglais : Motor neuron disease, Sporadic, Twin, United Kingdom, Europe, Environmental factor, Genetic parameter, Risk factor, Etiology, Human, Nervous system diseases, Central nervous system disease, Spinal cord disease, Degenerative disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0397355
Code Inist : 002B17G. Création : 12/09/1997.