Serum immunoglobulins and the risk of rheumatoid arthritis.
Rheumatoid arthritis (RA) is associated with several autoantibodies that can precede the clinical disease.
The immunoglobulin concentrations in serum samples before illness were studied to learn more about the immunological process before RA.
Methods-A case-control study was nested within a Finnish cohort of 19 072 adults who had neither arthritis nor a history of it at the baseline examination during 1973-1977.
By late 1989,124 had developed RA, of which 89 were positive for rheumatoid factor (RF).
Three controls per each incident case were individually matched for sex, age, and municipality.
The concentrations of IgG, IgA, and IgM were measured from stored serum samples.
Serum IgG before illness was found to be directly proportional to the risk of RF positive RA, and a non-linear association was present between serum IgA and the risk of RF positive RA.
These associations were constant between men and women and other subgroups of the study population and not confounded by serum orosomucoid concentration, level of education, smoking, alcohol intake or body mass index.
As adjusted for these factors, the odds ratios (95% confidence intervals) of RF positive RA in the lowest, mid, and highest tertiles of IgG distribution were 1.00,1.55 (0.81,2.97), and 2.22 (1.16,4.26), and in the tertiles of IgA 1.00,2.23 (1.14,4.36), and 1.78 (0.89,3.57), respectively. (...)
Mots-clés Pascal : Immunoglobuline, Sérum, Concentration, Polyarthrite rhumatoïde, Facteur risque, Analyse corrélation, Epidémiologie, Etude cas témoin, Adulte, Homme, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune
Mots-clés Pascal anglais : Immunoglobulins, Serum, Concentration, Rheumatoid arthritis, Risk factor, Correlation analysis, Epidemiology, Case control study, Adult, Human, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0397331
Code Inist : 002B15D. Création : 12/09/1997.