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  1. Effect of cleansing the birth canal with antiseptic solution on maternal and newborn morbidity and mortality in Malawi : clinical trial. Commentary.

    Article - En anglais

    Objective 

    To determine if cleansing the birth canal with an antiseptic at delivery reduces infections in mothers and babies postnatally.

    Design 

    Clinical trial ; two months of no intervention were followed by three months of intervention and a final month of no intervention.

    Setting 

    Queen Elizabeth Central Hospital (tertiary care urban hospital), Blantyre, Malawi.

    Subjects 

    A total of 6965 women giving birth in a six month period and their 7160 babies.

    Intervention 

    Manual wipe of the maternal birth canal with a 0.25% chlorhexidine solution at every vaginal examination before delivery.

    Babies born during the intervention were also wiped with chlorhexidine.

    Main outcome measures 

    Effects of the intervention on neonatal and maternal morbidity and mortality.

    Results 

    3635 women giving birth to 3743 babies were enrolled in the intervention phase and 3330 women giving birth to 3417 babies were enrolled in the non-intervention phase.

    There were no adverse reactions related to the intervention among the mothers or their children.

    Among infants born in the intervention phase, overall neonatal admissions were reduced (634/3743 (16.9'%) v 661/3417 (19.3%), P<0.01), as were admissions for neonatal sepsis (7.8 v 17.9 per 1000 live births, P<0.0002), overall neonatal mortality (28.6 v 36.9 per 1000 live births, P<0.06), and mortality due to infectious causes (2.4 v 7.3 per 1000 live births, P<0.005). (...)

    Mots-clés Pascal : Accouchement, Epidémiologie, Protocole thérapeutique, Désinfection, Facteur prédictif, Transmission mère enfant, Naissance, Prévention, Femelle, Homme, Essai clinique, Malawi, Afrique, Appareil génital femelle pathologie, Gestation, Education santé

    Mots-clés Pascal anglais : Delivery, Epidemiology, Therapeutic protocol, Disinfection, Predictive factor, Mother to child transmission, Birth, Prevention, Female, Human, Clinical trial, Malawi, Africa, Female genital diseases, Pregnancy, Health education

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0396605

    Code Inist : 002B20G01. Création : 12/09/1997.