To determine if cleansing the birth canal with an antiseptic at delivery reduces infections in mothers and babies postnatally.
Clinical trial ; two months of no intervention were followed by three months of intervention and a final month of no intervention.
Queen Elizabeth Central Hospital (tertiary care urban hospital), Blantyre, Malawi.
A total of 6965 women giving birth in a six month period and their 7160 babies.
Manual wipe of the maternal birth canal with a 0.25% chlorhexidine solution at every vaginal examination before delivery.
Babies born during the intervention were also wiped with chlorhexidine.
Effects of the intervention on neonatal and maternal morbidity and mortality.
3635 women giving birth to 3743 babies were enrolled in the intervention phase and 3330 women giving birth to 3417 babies were enrolled in the non-intervention phase.
There were no adverse reactions related to the intervention among the mothers or their children.
Among infants born in the intervention phase, overall neonatal admissions were reduced (634/3743 (16.9'%) v 661/3417 (19.3%), P<0.01), as were admissions for neonatal sepsis (7.8 v 17.9 per 1000 live births, P<0.0002), overall neonatal mortality (28.6 v 36.9 per 1000 live births, P<0.06), and mortality due to infectious causes (2.4 v 7.3 per 1000 live births, P<0.005). (...)
Mots-clés Pascal : Accouchement, Epidémiologie, Protocole thérapeutique, Désinfection, Facteur prédictif, Transmission mère enfant, Naissance, Prévention, Femelle, Homme, Essai clinique, Malawi, Afrique, Appareil génital femelle pathologie, Gestation, Education santé
Mots-clés Pascal anglais : Delivery, Epidemiology, Therapeutic protocol, Disinfection, Predictive factor, Mother to child transmission, Birth, Prevention, Female, Human, Clinical trial, Malawi, Africa, Female genital diseases, Pregnancy, Health education
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0396605
Code Inist : 002B20G01. Création : 12/09/1997.