Objectives The association between cumulative radon exposure and coronary heart disease mortality was studied in a retrospective cohort investigation of Newfoundland fluorspar miners.
Methods Multivariate Poisson regression techniques were used to estimate relative risks of coronary heart disease mortality by level of radon exposure.
Relative risks (RR) were adjusted by attained age, calendar period, duration of exposure, and smoking status.
Death from coronary heart disease was the outcome measure of interest and was identified by record linkage to the Canadian Mortality Database.
Results An elevated risk for mortality from coronary heart disease was observed among miners with a cumulative radon exposure exceeding 1000 working-level months [RR 1.5,95% confidence interval (95% Cl) 0.77-2.75]. The association between radon exposure and coronary heart disease was not statistically significant according to a test for trend across exposure categories (P=0.09).
The smokers were 1.8 times more likely than the nonsmokers to die from coronary heart disease (95% Cl 1.1-2.8).
Conclusions These results suggest a positive association between coronary heart disease and radon exposure.
However, these findings should be interpreted cautiously due to the inability to control for the confounding influence of other known risk factors of coronary heart disease.
Mots-clés Pascal : Radon, Toxicité, Mine, Spath fluor, Exposition professionnelle, Cardiopathie coronaire, Médecine travail, Etude cohorte, Canada, Amérique du Nord, Amérique, Terre Neuve, Homme, Epidémiologie, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Radon, Toxicity, Mine, Fluorspar, Occupational exposure, Coronary heart disease, Occupational medicine, Cohort study, Canada, North America, America, Newfoundland, Human, Epidemiology, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0391596
Code Inist : 002A08F02. Création : 12/09/1997.