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  1. Are deficits in the equilibrium system relevant to the clinical investigation of solvent-induced neurotoxicity ?

    Article - En anglais

    Objectives The diagnosis of solvent-induced chronic toxic encephalopathy is commonly based on case histories of exposure to solvents, symptoms, and deficits on psychometric tests.

    It has previously been demonstrated that long-term solvent-exposed workers have disturbances of the equilibrium system.

    The correlation between these disturbances and the diagnosis of chronic toxic encephalopathy has been analyzed in the present study.

    Materials and methods Sixty men, consecutively admitted due to the suspicion of this syndrome, were investigated and classified into 3 groups - solvent-induced chronic toxic encephalopathy, incipient chronic toxic encephalopathy and nonchronic toxic encephalopathy.

    They were all examined using an otoneurological test battery, including analysis of saccades, smooth pursuit, visual suppression of the vestibular ocular reflex, and dynamic posturography.

    Results Compared with healthy referents several of the subjects, even in the nonchronic toxic encephalopathy group, showed a reduced visual suppression ability, a prolonged latency of saccades, and pathological posturographic results.

    Some otoneurological tests correlated with the duration of exposure and the results of psychometric tests representing memory and perceptual skills.

    Nevertheless, there was no significant group correlation between the otoneurological findings and the diagnosis of chronic toxic encephalopathy. (...)

    Mots-clés Pascal : Solvant organique, Toxicité, Exposition professionnelle, Encéphalopathie, Chronique, Médecine travail, Homme, Trouble équilibre, Cervelet, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie

    Mots-clés Pascal anglais : Organic solvent, Toxicity, Occupational exposure, Encephalopathy, Chronic, Occupational medicine, Human, Equilibrium disorder, Cerebellum, Nervous system diseases, Central nervous system disease, Cerebral disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0391594

    Code Inist : 002B03L04. Création : 12/09/1997.