Objectives The objective of this study was to determine the cancer incidence of a cohort exposed to diatomaceous earth and cristobalite with special focus on lung cancer.
Methods The cohort was from a diatomaceous plant in northern Iceland and comprised 919 men and 423 women.
Diatomite, when heated, is transformed from amorphous to crystalline silica with a high cristobalite content and traces of quartz.
With the use of the identification number of all persons, a link was made with the Cancer Registry.
The expected number of malignancies was calculated on the basis of person-years of observation for 5-year age categories during the respective calendar period of the study multiplied by the specific incidence of cancer site for men and women in Iceland.
Results There was no increased overall incidence of cancer in the study population ; 5 cases of lung cancer were observed versus 4.4 expected, the standardized incidence ratio (SIR) was 1.14 [95% confidence interval (95% CI) 0.37-2.65]. When the men in the cohort were divided according to their length of employment, there was an excess of lung cancer (3 observed versus 1.28 expected, SIR 2.34,95% CI 0.48-4.85), nonmelanoma skin cancer (2 observed versus 0.19 expected, SIR 10.53,95% Cl 1.27--38.02), and brain cancer (3 observed versus 0.30 expected, SIR 10.00,95% Cl 2.06-29.23) for those who had worked 5 years or longer. (...)
Mots-clés Pascal : Islande, Iles Atlantiques, Epidémiologie, Prévalence, Tumeur maligne, Bronchopulmonaire, Etude cohorte, Homme, Exposition professionnelle, Médecine travail, Diatomite, Toxicité, Carcinogène, Silice, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Cristobalite
Mots-clés Pascal anglais : Iceland, Atlantic Ocean Islands, Epidemiology, Prevalence, Malignant tumor, Bronchopulmonary, Cohort study, Human, Occupational exposure, Occupational medicine, Diatomite, Toxicity, Carcinogen, Silica, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0391591
Code Inist : 002B11A. Création : 12/09/1997.