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  1. Funding for patient-oriented research : Critical strain on a fundamental linchpin.

    Article - En anglais

    Context. - Interest in clinical investigative careers has declined over the past 2 decades.

    While several factors are likely involved in this decline, one is the perceived difficulty in obtaining support for investigator-initiated clinical research projects.


    - To analyze the priority scores and funding rates of patient-oriented research (POR) compared with laboratory-oriented research (LOR) when grant applications to the National Institutes of Health (NIH) are reviewed by study sections of the NIH Division of Research Grants.


    - Research grant applications submitted to NIH were classified by the applicant as involving human subjects or not (LOR).

    Those classified as involving human subjects were divided into clinical (POR) and nonclinical research.

    The association of priority score and POR or LOR status was evaluated using X2 statistical techniques.

    Setting and Participants

    - Twelve thousand investigator-initiated grant applications (R01s) in 2 of the 1994 NIH review cycles.

    Main Outcome Measures

    - Grant application priority scores and funding rates.


    - On the basis of the following 3 criteria, POR applications fare less well than LOR applications :

    • (1) POR status and ranking in the total application pool ;

    • (2) percentage of POR vs LOR applications in the top 20th percentile ;

    • and (3) funding rates of POR applications.

    Furthermore, the fate of a POR application depended on which study section reviewed the application. (...)

    Mots-clés Pascal : Recherche scientifique, Méthode étude, Evaluation, Programme application, Malade, Laboratoire, Intérêt, Coût, Homme, Organisation santé

    Mots-clés Pascal anglais : Scientific research, Investigation method, Evaluation, Application program, Patient, Laboratory, Interest, Costs, Human, Public health organization

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0388375

    Code Inist : 002B30A09. Création : 12/09/1997.