logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Regional cancer cytogenetics : A report on 1,143 diagnostic cases.

    Article - En anglais

    The results of studies from a regional cancer cytogenetics diagnostic service are reported.

    In a 10-year period, 1,143 marrow samples from patients with newly diagnosed leukemia and myelodysplastic syndrome were referred.

    Successful studies were completed on 992 cases (87%). Among all referred cases, the rates of detection of cytogenetically abnormal clones were 95% for chronic myelogenous leukemia (CML), 54% for acute lymphoblastic leukemia (ALL), 51% for acute myeloid leukemia (ANLL), and 43% for myelodysplastic syndrome (MDS).

    Of 169 cases of CML studied, 90.5% bore the standard Philadelphia chromosome (Ph), 3.55% had an unusual Ph, and 5.33% were Ph-negative.

    Among the 59 cases of cytogenetically abnormal MDS, common abnormalities observed were trisomy 8 and changes resulting in loss of material from the long arm of chromosomes 5 and 7, and 20q-Of the 168 abnormal ANLL, there was a strikingly non-random pattern of aneuploidy, with monosomy 7 and trisomy 8 predominating.

    Common structural changes observed were changes resulting in loss of material from the long arm of chromosomes 5 and 7, trisomy 8, rearrangements of 11q23, t (15 ; 17), t (8 ; 21), rearrangements of 12q13 and 3q, inversion 16, trisomy 11, Ph, trisomy 21, t (6 ; 9) and t (1 ; 22).

    The differences between adult and pediatric findings were minor, with the exception of chromosome 5 abnormalities, which were common among adults with ANLL but rare in the pediatric cases. (...)

    Mots-clés Pascal : Leucémie, Myélodysplasique syndrome, Epidémiologie, Cytogénétique, Etude statistique, Canada, Amérique du Nord, Amérique, Etude multicentrique, Homme, Organisme régional, Hémopathie maligne, Génétique

    Mots-clés Pascal anglais : Leukemia, Myelodysplastic syndrome, Epidemiology, Cytogenetics, Statistical study, Canada, North America, America, Multicenter study, Human, Regional institution, Malignant hemopathy, Genetics

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0387937

    Code Inist : 002B19B. Création : 12/09/1997.