The results of studies from a regional cancer cytogenetics diagnostic service are reported.
In a 10-year period, 1,143 marrow samples from patients with newly diagnosed leukemia and myelodysplastic syndrome were referred.
Successful studies were completed on 992 cases (87%). Among all referred cases, the rates of detection of cytogenetically abnormal clones were 95% for chronic myelogenous leukemia (CML), 54% for acute lymphoblastic leukemia (ALL), 51% for acute myeloid leukemia (ANLL), and 43% for myelodysplastic syndrome (MDS).
Of 169 cases of CML studied, 90.5% bore the standard Philadelphia chromosome (Ph), 3.55% had an unusual Ph, and 5.33% were Ph-negative.
Among the 59 cases of cytogenetically abnormal MDS, common abnormalities observed were trisomy 8 and changes resulting in loss of material from the long arm of chromosomes 5 and 7, and 20q-Of the 168 abnormal ANLL, there was a strikingly non-random pattern of aneuploidy, with monosomy 7 and trisomy 8 predominating.
Common structural changes observed were changes resulting in loss of material from the long arm of chromosomes 5 and 7, trisomy 8, rearrangements of 11q23, t (15 ; 17), t (8 ; 21), rearrangements of 12q13 and 3q, inversion 16, trisomy 11, Ph, trisomy 21, t (6 ; 9) and t (1 ; 22).
The differences between adult and pediatric findings were minor, with the exception of chromosome 5 abnormalities, which were common among adults with ANLL but rare in the pediatric cases. (...)
Mots-clés Pascal : Leucémie, Myélodysplasique syndrome, Epidémiologie, Cytogénétique, Etude statistique, Canada, Amérique du Nord, Amérique, Etude multicentrique, Homme, Organisme régional, Hémopathie maligne, Génétique
Mots-clés Pascal anglais : Leukemia, Myelodysplastic syndrome, Epidemiology, Cytogenetics, Statistical study, Canada, North America, America, Multicenter study, Human, Regional institution, Malignant hemopathy, Genetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0387937
Code Inist : 002B19B. Création : 12/09/1997.