Styrene-7,8-oxide (SO), the major in vivo metabolite of styrene, is a genotoxic compound and a potential carcinogenic hazard to occupationally exposed workers.
The aim of the present work was to investigate the ability of styrene exposure to induce formation of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in white blood cells (WBC) of boatbuilders occupationally exposed to styrene.
The study of these adducts was conducted to see if styrene exposure can cause oxidative damage of DNA.
The 8-OHdG/105 dG ratio from 17 styrene-exposed workers showed significant increases (mean ± SD, 2.23 ± 0.54, median 2.35, P<0.001) in comparison to the controls (1.52 ± 0.45, median 1.50).
However, 11 out of 17 workers who were between the ages of 32 and 60 years and had been occupationally exposed to styrene for>10 years showed higher 8-OHdG/105 dG ratios (2.31 ± 0.62, median 2.37) in comparison to 6 workers with<6 years of occupational styrene-exposure (2.11 ± 0.36, median 2.05 ; P>0.05, no significant difference between the two groups of workers).
The studies presented here provide an indication that styrene exposure can result in oxidative DNA damage.
Mots-clés Pascal : Styrène, Solvant organique, Toxicité, Exposition professionnelle, Médecine travail, Homme, Leucocyte, Surveillance biologique, Marqueur biologique, DNA, Adduit moléculaire, Carcinogène, Désoxyguanosine(8-hydroxy)
Mots-clés Pascal anglais : Styrene, Organic solvent, Toxicity, Occupational exposure, Occupational medicine, Human, Leukocyte, Biological monitoring, Biological marker, DNA, Molecular adduct, Carcinogen
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0387364
Code Inist : 002B03L04. Création : 12/09/1997.