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  1. Fiber analysis in lungs of residents of a Japanese town with endemic pleural plaques.

    Article - En anglais

    The authors analyzed various types of fibers in lung-tissue samples, which were obtained from 50 cases (46 surgical resections and 4 autopsies) at Kumamoto-Minami Hospital in Matsubase, where the occurrence of pleural plaques is endemic.

    Lung cancer necessitated surgical resection in 44 cases.

    Eleven of the 50 cases were residents of Matsubase ; 15 resided in the region around the town, where the frequency of pleural plaques was slightly higher ; and 24 cases lived in a region with normal plaque frequency.

    The number of anthophyllite fibers in the lungs of town residents was significantly higher than in residents of the region with normal plaque frequency.

    In 6 cases, the authors found accompanying pleural plaques, and the anthophyllite fiber count in the lungs in these cases was significantly higher than in cases without plaques.

    In addition, the anthophyllite fiber counts in 2 cases with severe plaques were significantly higher in 4 cases with only mild plaques.

    These results suggested that anthophyllite fiber might be responsible for the increased prevalence of pleural plaques in Matsubase.

    Even though the anthophyllite fibers were quite long (mean length=25.1 mum), the width of most anthophyllite fibers were thick (mean diameter=0.84 mum).

    Therefore, the aspect ratio of anthophyllite (mean=38.7) was lower than that of amosite (mean=81.8), which, in a previous report, was found predominantly in cases of pleural mesothelioma. (...)

    Mots-clés Pascal : Fibre minérale, Poumon, Toxicité, Plaque pleurale, Appareil respiratoire pathologie, Milieu urbain, Homme, Japon, Asie, Epidémiologie, Amiante, Matériel autopsie, Anthophyllite

    Mots-clés Pascal anglais : Mineral fiber, Lung, Toxicity, Pleural plate, Respiratory disease, Urban environment, Human, Japan, Asia, Epidemiology, Asbestos, Autopsy material

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0387277

    Code Inist : 002B03L03. Création : 12/09/1997.