Epidemiology of coagulation factors, inhibitors and activation markers : The Third Glasgow MONICA survey. II. Relationships to cardiovascular risk factors and prevalent cardiovascular disease.
Coagulation factor activity (fibrinogen.
VII, VIII and IX), coagulation inhibitor activity (antithrombin. protein C, protein S), and coagulation activation markers (prothrombin fragment F1,2 ; thrombin-antithrombin complexes) were measured in 746 men and 816 women aged 25-74 years, randomly sampled from the north Glasgow population in the Third MONICA Survey.
After age-adjustment, significant associations with cardiovascular risk factors were observed.
Serum cholesterol and triglyceride were associated with increases in factors VII and IX. as well as antithrombin, protein C and protein S ; and with increased fibrinogen and factor VIII in women.
Apart from factor VIII (related to blood pressure in men, but not in women), similar associations were observed for blood pressure and body mass index.
Smoking status and/or smoking markers were related to fibrinogen. factor IX. antithrombin and protein S. Alcohol intake was related to protein S, and inversely to fibrinogen and antithrombin in men.
Low social class was associated with fibrinogen, factor VIII, factor IX, and with antithrombin, protein S, and low protein C in men.
Serum vitamin C was associated inversely with coagulation factors and coagulation inhibitors.
The only associations of activation markers were with low serum vitamin C, and with alcohol consumption and low social class in men.
Prevalent cardiovascular disease was associated only with fibrinogen. (...)
Mots-clés Pascal : Cardiopathie coronaire, Artère pathologie, Cérébrovasculaire pathologie, Facteur coagulation, Inhibiteur, Plasma sanguin, Activation, Marqueur biologique, Homme, Facteur risque, Epidémiologie, Association, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Système nerveux pathologie, Encéphale pathologie, Système nerveux central pathologie, Coagulation sanguine
Mots-clés Pascal anglais : Coronary heart disease, Arterial disease, Cerebrovascular disease, Coagulation factor, Inhibitor, Blood plasma, Activation, Biological marker, Human, Risk factor, Epidemiology, Association, Cardiovascular disease, Vascular disease, Nervous system diseases, Cerebral disorder, Central nervous system disease, Blood coagulation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0385118
Code Inist : 002B12B03. Création : 12/09/1997.