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  1. The VITA Project : C677T mutation in the methylene-tetrahydrofolate reductase gene and risk of venous thromboembolism.

    Article - En anglais

    We evaluated the hypothesis that a common polymorphism of the methylenetetrahydrofolate reductase gene (C677T), which results in increased levels of plasma homocysteine, may be a putative risk factor for venous thromboembolism (VT).

    Sixty-five cases of VT and 130 controls, both identified within the framework of an epidemiologic survey on thrombophilia, the Vicenza Thrombophilia and Arteriosclerosis (VITA) Project, were genotyped for the mutation.

    No increased risk of VT was found in carriers of the mutation.

    We conclude that screening for the C677T mutation of the methylenetetrahydrofolate reductase gene should not be recommended in unselected patients with VT.

    Mots-clés Pascal : Thrombose, Veine profonde, Thromboembolie, Facteur risque, Marqueur génétique, Homme, Methylenetetrahydrofolate reductase (NADPH), Oxidoreductases, Enzyme, Mutation, Exploration, Epidémiologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Veine pathologie

    Mots-clés Pascal anglais : Thrombosis, Deep vein, Thromboembolism, Risk factor, Genetic marker, Human, Methylenetetrahydrofolate reductase (NADPH), Oxidoreductases, Enzyme, Mutation, Exploration, Epidemiology, Cardiovascular disease, Vascular disease, Venous disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0385015

    Code Inist : 002B12B03. Création : 12/09/1997.