logo BDSP

Base documentaire

  1. Antihypertensives and the risk of serious hypoglycemia in older persons using insulin or sulfonylureas.

    Article - En anglais

    Context. bêta-Blockers and angiotensin-converting enzyme (ACE) inhibitors are effective antihypertensive agents for patients with diabetes mellitus.

    However, bêta-blockers attenuate some components of the autonomic response to hypoglycemia and could increase the risk of hypoglycemia.

    ACE inhibitors may increase insulin sensitivity and predispose users to hypoglycemia.


    - To determine whether use of cardioselective bêta-blockers, nonselective bêta-blockers, ACE inhibitors, thiazide diuretics, calcium channel blockers, or other antihypertensive drugs alters the risk of developing serious hypoglycemia among older persons prescribed insulin or sulfonylureas.


    - Retrospective cohort study.


    - Tennessee Medicaid Program.


    - A total of 13 559 elderly (mean age, 78±7 years) Medicaid enrollees, who were prescribed insulin in=5171,38%) or sulfonylureas (n=8368,62%) from 1985 through 1989.

    These enrollees contributed a total of 33 107 person-years of insulin or sulfonylurea use for follow-up.


    - Hospitalization, emergency department admission, or death associated with hypoglycemic symptoms and a concomitant blood glucose determination of less than 2.8 mmol/L (50 mg/dL).


    - We identified 598 persons with an episode of serious hypoglycemia during the study period.

    The rate of serious hypoglycemia was 2.01 per 100 person-years among those who were not prescribed antihypertensives. (...)

    Mots-clés Pascal : Hypertension artérielle, Diabète, Etude cohorte, Antihypertenseur, Interaction médicamenteuse, Sulfonylurées, Hypoglycémie, Facteur risque, Vieillard, Homme, Prévention, Rétrospective, Peptidyl-dipeptidase A, Peptidyl-dipeptidases, Peptidases, Hydrolases, Enzyme, Bloquant bêta-adrénergique, Glucose, Appareil circulatoire pathologie, Endocrinopathie, Pancréas pathologie

    Mots-clés Pascal anglais : Hypertension, Diabetes mellitus, Cohort study, Antihypertensive agent, Drug interaction, Sulfonylureas, Hypoglycemia, Risk factor, Elderly, Human, Prevention, Retrospective, Peptidyl-dipeptidase A, Peptidyl-dipeptidases, Peptidases, Hydrolases, Enzyme, Beta blocking agent, Glucose, Cardiovascular disease, Endocrinopathy, Pancreatic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0381073

    Code Inist : 002B02F05. Création : 12/09/1997.