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  1. Immunization of HIV-infected adults with a three-dose series of inactivated mycobacterium vaccae.

    Article - En anglais

    Heat-killed Mycobacterium vaccae vaccine was administered in a 3-dose schedule to 12 HIV-infected adults with CD4 cell counts = 300/mm3.

    Local and systemic side effects were monitored.

    Delayed-type hypersensitivity to purified protein derivative and Mycobacterium avium sensitin was measured at baseline and after the final dose.

    Antibody to aralipoarabinomannin, man-lipoarabinomannin, and a short-term culture filtrate of Mycobacterium tuberculosis were also measured.

    Lymphocyte proliferation responses to M avium sensitin and M vaccae sonicate were determined.

    Vaccine site induration was maximal at 2 days (median, 6 mm) and no systemic side effects were noted.

    Purified protein derivative skin test conversions did not occur.

    Changes in CD4 counts and HIV viral load were not significant.

    Three (27%) of 11 subjects who completed the trial showed either M avium skin test (n=1) or short-term culture filtrate antibody (n=2) responses.

    A three-dose schedule of M vaccae vaccine is safe and well tolerated in adults with early HIV infection and produces detectable immunologic responses in a subset of these subjects.

    Mots-clés Pascal : SIDA, Virose, Infection, Immunoprophylaxie, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Mycobacterium vaccae, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bactérie, Test 3 phases, Dose efficace, BCG, Vaccin, Etude comparative, Evaluation, Homme, Immunopathologie, Immunodéficit, Mycobactériose, Bactériose, Vaccination

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Immunoprophylaxis, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Mycobacterium vaccae, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bacteria, Three phase test, Effective dose, BCG, Vaccine, Comparative study, Evaluation, Human, Immunopathology, Immune deficiency, Mycobacterial infection, Bacteriosis, Vaccination

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0381002

    Code Inist : 002B06D01. Création : 12/09/1997.