Tuberculosis in the United States has become primarily an inner-city disease.
We examined the epidemiology of culture-confirmed tuberculous meningitis among patients cared for at an urban public hospital in Atlanta.
During an 11.5-year period (January 1984-June 1995) cerebrospinal fluid cultures for Mycobacterium tuberculosis were positive in 34 patients, accounting for 1.5% of all culture-confirmed tuberculosis cases.
All patients were born in the United States, 31 (91%) were black, 16 (47%) of 34 were human immunodeficiency virus (HIV) seropositive, 9 (26.5%) were HIV seronegative, and 9 (26.5%) had an unknown HIV serostatus.
No significant differences were seen in clinical presentation, cerebrospinal fluid, or other laboratory data between HIV seropositive and HIV seronegative/unknown groups, except for a lower serum white blood cell count among HIV seropositive patients.
Mortality was striking ; 14 (41.2%) died because of tuberculous meningitis despite appropriate therapy initiated a mean of 3 days after admission.
Six survivors had permanent neurologic sequelae.
Univariate analysis of outcome was not statistically associated with any measured demographic, laboratory value, stage at presentation, treatment regimen, or HIV serostatus.
Multivariate analysis of outcome using 13 independent variables also demonstrated no significant association between these variables and outcome, although a trend was seen for increased mortality for white people (P=0. (...)
Mots-clés Pascal : Méningite, Tuberculose, Mycobactériose, Bactériose, Infection, Epidémiologie, SIDA, Virose, Bidonville, Facteur risque, Exploration bactériologique, Etude comparative, Centre santé, Evaluation, Homme, Etats Unis, Amérique du Nord, Amérique, Système nerveux pathologie, Système nerveux central pathologie, Organisation santé, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : Meningitis, Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, Epidemiology, AIDS, Viral disease, Shantytown, Risk factor, Bacteriological investigation, Comparative study, Health center, Evaluation, Human, United States, North America, America, Nervous system diseases, Central nervous system disease, Public health organization, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0380604
Code Inist : 002B05B02O. Création : 12/09/1997.