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  1. The application of meta-analysis in assessing racial differences in the effects of antihypertensive medication.

    Article - En anglais

    Meta-analysis is an important technique for synthesizing research findings.

    Although the statistical foundations of meta-analysis continue to be debated, few question its value as a rigorous framework for organizing literature reviews.

    In recent years, there has been increasing emphasis on the use of meta-analysis not only to summarize the central tendency of findings but also to explain variation between studies.

    This article reviews the major steps in a meta-analysis with an emphasis on comparative analysis of subgroups of studies.

    A meta-analysis of the antihypertensive efficacy of calcium channel blockers is used to illustrate how a comparative analysis can be applied to investigate racial variation in the effects of calcium channel blockers.

    A statistically significant trend is found between the proportion of African-American hypertensive subjects and the mean reduction in blood pressure.

    Meta-analytic techniques also are applied to explore possible confounders due to differences in research design and patient characteristics.

    Mots-clés Pascal : Hypertension artérielle, Métaanalyse, Prévalence, Race, Africain, Américain, Antihypertenseur, Calcium, Pression sanguine, Analyse statistique, Homme, Etats Unis, Amérique du Nord, Amérique, Article synthèse, Appareil circulatoire pathologie, Politique sanitaire

    Mots-clés Pascal anglais : Hypertension, Metaanalysis, Prevalence, Race, African, American, Antihypertensive agent, Calcium, Blood pressure, Statistical analysis, Human, United States, North America, America, Review, Cardiovascular disease, Health policy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0380506

    Code Inist : 002B12B05B. Création : 12/09/1997.