Meta-analysis is an important technique for synthesizing research findings.
Although the statistical foundations of meta-analysis continue to be debated, few question its value as a rigorous framework for organizing literature reviews.
In recent years, there has been increasing emphasis on the use of meta-analysis not only to summarize the central tendency of findings but also to explain variation between studies.
This article reviews the major steps in a meta-analysis with an emphasis on comparative analysis of subgroups of studies.
A meta-analysis of the antihypertensive efficacy of calcium channel blockers is used to illustrate how a comparative analysis can be applied to investigate racial variation in the effects of calcium channel blockers.
A statistically significant trend is found between the proportion of African-American hypertensive subjects and the mean reduction in blood pressure.
Meta-analytic techniques also are applied to explore possible confounders due to differences in research design and patient characteristics.
Mots-clés Pascal : Hypertension artérielle, Métaanalyse, Prévalence, Race, Africain, Américain, Antihypertenseur, Calcium, Pression sanguine, Analyse statistique, Homme, Etats Unis, Amérique du Nord, Amérique, Article synthèse, Appareil circulatoire pathologie, Politique sanitaire
Mots-clés Pascal anglais : Hypertension, Metaanalysis, Prevalence, Race, African, American, Antihypertensive agent, Calcium, Blood pressure, Statistical analysis, Human, United States, North America, America, Review, Cardiovascular disease, Health policy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0380506
Code Inist : 002B12B05B. Création : 12/09/1997.