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  1. Racial differences in breast cancer survival : The interaction of socioeconomic status and tumor biology.

    Article - En anglais

    OBJECTIVE 

    Our purpose was to evaluate the effect of sociodemographic and clinical variables on survival rates of African-American and white women with breast cancer.

    STUDY DESIGN 

    Between 1988 and 1992 the Metropolitan Detroit Cancer Surveillance System identified 10,502 women (82% white and 18% African-American) in whom invasive breast cancer was diagnosed.

    Cox proportional hazards regression was used to estimate the relative risk of death for African-Americans compared with whites after controlling for variables believed to influence survival.

    RESULTS 

    African-American women were more likely than white women to have tumors that were of a more advanced stage, a higher grade, and hormone receptor-negative.

    After controlling for age, tumor size, stage, histologic grade, census-derived socioeconomic status, and the presence of a residency training program at the treatment hospital, the relative risk of dying for African-Americans compared with whites was 1.68 (95% confidence interval, 1.27-2.23) for women less than 50 years of age, and 1.33 (95% confidence interval, 1.13-1.56) for women older than 50 years of age.

    CONCLUSIONS 

    Known factors that predict survival differences between African-Americans and whites are more prevalent among women less than 50 years of age, emphasizing the need to focus more attention on public heath efforts directed toward younger women.

    Mots-clés Pascal : Carcinome, Glande mammaire, Evaluation, Survie, Effet biologique, Race, Statut socioéconomique, Grade histologique, Etude comparative, Homme, Femelle, Tumeur maligne, Glande mammaire pathologie

    Mots-clés Pascal anglais : Carcinoma, Mammary gland, Evaluation, Survival, Biological effect, Race, Socioeconomic status, Histological grading, Comparative study, Human, Female, Malignant tumor, Mammary gland diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0380307

    Code Inist : 002B20E02. Création : 12/09/1997.