logo BDSP

Base documentaire

  1. Vitamin D-receptor gene polymorphisms and bone density in prepubertal American girls of Mexican descent.

    Article - En anglais

    Background Bone mass is under strong genetic control, and recent studies in adults have suggested that allelic differences in the gene for the vitamin D receptor may account for inherited variability in bone mass.

    We studied the relations of the vitamin D-receptor genotype to skeletal development and variation in the size, volume, and density of bone in children.

    Methods We identified three allelic variants of the vitamin D-receptor gene using the polymerase chain reaction and three restriction enzymes (Apal, Bsml, and Taql) in 100 normal prepubertal American girls of Mexican descent.

    We then determined the relations of the different vitamin D-receptor genotypes (AA, Aa, aa, BB, Bb, bb, TT, Tt, and tt) to the cross-sectional area, cortical area, and cortical bone density of the femoral shaft and the cross-sectional area and density of the lumbar vertebrae.

    Results The vitamin D-receptor genotype was associated with femoral and vertebral bone density.

    Girls with aa and bb genotypes had 2 to 3 percent higher femoral bone density (P=0.008 and P=0.04, respectively) and 8 to 10 percent higher vertebral bone density (P=0.01 and P=0.03, respectively) than girls with AA and BB genotypes.

    There was no association between the cross-sectional area of the vertebrae or the cross-sectional or cortical area of the femur and the vitamin D-receptor genotype. (...)

    Mots-clés Pascal : Masse osseuse, Etude comparative, Réaction chaîne polymérase, Vitamine D, Gène régulateur, Développement staturopondéral, Prépuberté, Déterminisme génétique, Américain, Mexique, Amérique Centrale, Amérique, Homme, Evaluation, Femelle, Epidémiologie, Etude transversale, Système ostéoarticulaire pathologie, Métabolisme pathologie, Nutrition, Vitamine, Pédiatrie

    Mots-clés Pascal anglais : Bone mass, Comparative study, Polymerase chain reaction, Vitamin D, Regulator gene, Somatic growth, Prepuberty, Genetic inheritance, American, Mexico, Central America, America, Human, Evaluation, Female, Epidemiology, Cross sectional study, Diseases of the osteoarticular system, Metabolic diseases, Nutrition, Vitamin, Pediatrics

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0380205

    Code Inist : 002B15I. Création : 12/09/1997.