Colorectal cancer risk in HNPCC families : Development during lifetime and in successive generations.
Members of hereditary non-polyposis colorectal cancer (HNPCC) families develop colorectal cancer at a much higher rate, and at a much younger age, than the general population.
To quantify lifetime colorectal cancer risk in HNPCC family members, we calculated the cumulative incidence (Cl) in different age categories, and compared this to the general population.
Furthermore, we investigated whether successive generations of HNPCC families had earlier onset of disease.
In 51 HNPCC families, selected according to the « Amsterdam criteria », the Cl of colorectal cancer at age 75 was 40%, compared to only 4% in the general population.
The Cl ratio (CIR) of HNPCC family members relative to the general population was 148 at age 40,79 at age 50 and I at age 75.
Comparing successive generations of HNPCC families, the Cl at age 75 increases from 19% in the ancestors to 32% in the first generation and 55% in the second generation.
However, Cox proportional hazard analysis showed that this generation effect (RR per generation : 1.8,95% CL=1.4-2.2) largely disappears after adjustment for year of birth.
In, at young ages, HNPCC family members experience an up-to-150 times higher risk for colorectal cancer than the general population.
This risk difference declines from age 60 onwards. (...)
Mots-clés Pascal : Carcinome, Côlon, Rectum, Epidémiologie, Analyse risque, Homme, Etude multigénération, Etude familiale, Etude longitudinale, Registre, Pays Bas, Europe, Héréditaire, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Cancer familial, Lynch syndrome
Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Epidemiology, Risk analysis, Human, Multigeneration study, Family study, Follow up study, Register, Netherlands, Europe, Hereditary, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Familial cancer, Lynch syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0378538
Code Inist : 002B13B01. Création : 12/09/1997.