Clinicoepidemiological, toxicological, and safety evaluation studies on argemone oil.
Consumption of oil extracted from accidental or deliberate contamination of argemone seed to mustard seed is known to pose a clinical condition popularly referred to as Epidemic Dropsy.
Several outbreaks of Epidemic Dropsy have occurred in the past in India as well as in Mauritius, Fiji Island, and South Africa.
Clinico-epidemiological manifestations of argemone oil poisoning include vomiting, diarrhea, nausea, swelling of limbs, erythema, pitting edema, breathlessness, etc.
In extreme cases, glaucoma and even death due to cardiac arrest have been encountered.
The toxicity of argemone oil has been attributed to two of its physiologically active benzophenanthridine alkaloids, sanguinarine and dihydrosanguinarine.
Histopathological studies suggest that liver, lungs, kidney, and heart are the target sites for argemone oil intoxication.
Studies have shown to elucidate the cocarcinogenic potential of argemone oil that can be correlated with the binding of sanguinarine with a DNA template.
Pharmacological response in intestine revealed immediate stimulation of tone and peristaltic movements of the gut in the sanguinarine-treated animals.
Argemone oil/Sanguinarine caused a decrease in hepatic glycogen levels which may be due to the activation of glycogenolysis leading to an accumulation of pyruvate in the blood of Epidemic Dropsy cases.
The increase in pyruvate levels causes uncoupling of oxidative phosphorylation leading to breathlessness, as observed in patients. (...)
Mots-clés Pascal : Huile alimentaire, Epidémiologie, Huile végétale, Toxicité, Inde, Asie, Contamination, Adultération, Huile moutarde, Papaveraceae, Dicotyledones, Angiospermae, Spermatophyta, Alcaloïde, Mécanisme action, Enfant, Homme, Hydropisie, Symptomatologie, Animal, Traitement, Chimiothérapie, Prévention, Intoxication alimentaire, Carcinogène, Argemone mexicana
Mots-clés Pascal anglais : Edible oil, Epidemiology, Vegetal oil, Toxicity, India, Asia, Contamination, Adulteration, Mustard oil, Papaveraceae, Dicotyledones, Angiospermae, Spermatophyta, Alkaloid, Mechanism of action, Child, Human, Dropsy, Symptomatology, Animal, Treatment, Chemotherapy, Prevention, Food poisoning, Carcinogen
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0377983
Code Inist : 002B03H. Création : 12/09/1997.