This review identified and evaluated 25 epidemiologic studies pertaining to the carcinogenicity of mists containing sulfuric acid (MSA).
Few studies were designed with acid mists as the principal exposure under investigation, and in all studies exposure assessment was limited.
The results of the follow-up studies from industries with high or moderate exposure potential and the case-control studies indicate, in aggregate, a moderate association between MSA and larynx cancer.
The data suggest a dose-response relationship.
However, many of the results from individual studies are imprecise, and confounding by smoking, alcohol, and other occupational agents is not adequately adjusted for.
The biologic plausibility and the possible carcinogenic mechanism remain uncertain.
There is little evidence in support of a causal relationship between exposure to MSA and lung cancer.
Information is inadequate for drawing any meaningful inference about the association between exposure to MSA and nasal cancer.
Mots-clés Pascal : Brouillard, Aérosol, Sulfurique acide, Epidémiologie, Carcinogène, Tumeur maligne, Bronchopulmonaire, Homme, Exposition professionnelle, Médecine travail, Larynx, Nez, Voie respiratoire, Etats Unis, Amérique du Nord, Amérique, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Toxicité
Mots-clés Pascal anglais : Fog, Aerosols, Sulfuric acid, Epidemiology, Carcinogen, Malignant tumor, Bronchopulmonary, Human, Occupational exposure, Occupational medicine, Larynx, Nose, Respiratory tract, United States, North America, America, Respiratory disease, Lung disease, Bronchus disease, Toxicity
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0377980
Code Inist : 002B03M02. Création : 12/09/1997.