Heterosexual transmission of hepatitis C virus among married couples in Southwestern Japan.
The heterosexual transmission of hepatitis C virus (HCV) remains controversial, and data from general populations are scanty.
In this cross-sectional study, we assessed the seroprevalence of antibodies to hepatitis C virus (anti-HCV) and the presence and genotype of HCV-RNA among 109 married couples within an endemic, community-based Japanese population.
Overall, 25% of the husbands and 32% of the wives had anti-HCV.
Spouses with anti-HCV-positive partners were around 2 times more likely to have anti-HCV than spouses with anti-HCV-negative partners (p=0.01).
Of 6 couples in which both spouses had HCV-RNA, however, 3 presented discordant HCV genotypes (type 1b vs. 2b).
The couples'anti-HCV concordance status was not significantly influenced by the presence or absence of HCV-RNA among anti-HCV-positive partners (odds ratio [OR] : 0.8 for wives, 0.6 for husbands), nor by the length of marriage, the number of pregnancies or the use of contraceptives.
No significant associations with anti-HCV were observed for serum markers of sexually transmitted agents, including human T-lymphotropic virus (OR=1.1,95% confidence interval [Cl] 0.5-2.3), Treponema pallidum (OR=0.7 ; Cl 0.1-6.1) and hepatitis B virus (OR=1.6 ; Cl 0.9-3.0).
Our results suggest that the clustering of HCV infection among specific couples within this endemic population may not be attributable to heterosexual transmission. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Homme, Virus hépatite C, Flaviviridae, Virus, Transmission, Epidémiologie, Relation sexuelle, Hétérosexualité, Partenaire sexuel, Conjoint, Sérologie, Etude transversale, Japon, Asie, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Human, Hepatitis C virus, Flaviviridae, Virus, Transmission, Epidemiology, Sexual intercourse, Heterosexuality, Sex partner, Spouse, Serology, Cross sectional study, Japan, Asia, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0370406
Code Inist : 002B05C02G. Création : 12/09/1997.