Use of inhaled corticosteroids and the risk of cataracts.
Background The use of systemic corticosteroids is a risk factor for the development of posterior subcapsular cataracts, but the association between inhaled corticosteroids and cataracts is uncertain.
Methods We conducted a population-based, cross-sectional study of vision and common eye diseases in an urban area of the Blue Mountains, near Sydney, Australia.
We recruited 3654 people 49 to 97 years of age ; the participation rate was 82 percent.
We collected information by questionnaire on potential risk factors for cataracts, including the current or prior use of inhaled corticosteroids (beclomethasone or budesonide).
Photographs of the subjects'lenses were graded, without information on the subjects, to determine the presence and severity of cortical, nuclear, and posterior subcapsular cataracts.
Results Three hundred seventy subjects reported using inhaled corticosteroids, 164 currently and 206 previously.
Among these subjects, after adjustment for age and sex, there was a higher prevalence of nuclear cataracts (relative prevalence, 1.5 ; 95 percent confidence interval, 1.2 to 1.9) and posterior subcapsular cataracts (relative prevalence, 1.9 ; 95 percent confidence interval, 1.3 to 2.8) than among the subjects with no inhaled-corticosteroid use, but the prevalence of cortical cataracts was not significantly higher (relative prevalence, 1.1 ; 95 percent confidence interval, 0.9 to 1.3). (...)
Mots-clés Pascal : Chimiothérapie, Corticostéroïde, Inhalation, Complication, Iatrogène, Toxicité, Cataracte, Evaluation, Risque, Questionnaire, Epidémiologie, Homme, Pharmacovigilance, Toxicologie, Oeil pathologie, Cristallin pathologie, Segment antérieur pathologie
Mots-clés Pascal anglais : Chemotherapy, Corticosteroid, Inhalation, Complication, Iatrogenic, Toxicity, Cataract, Evaluation, Risk, Questionnaire, Epidemiology, Human, Pharmacovigilance, Toxicology, Eye disease, Lens disease, Anterior segment disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0370050
Code Inist : 002B02U09. Création : 12/09/1997.