To assess factors that affect cisplatin nephrotoxicity.
In 425 patients treated with cisplatin, we assessed the effect of pretreatment factors and treatment conditions on the rise in serum creatinine with the first course of cisplatin, on the maximum rise in serum creatinine over the entire course of the cisplatin therapy, and on residual nephrotoxicity after the last cisplatin treatment ended. (Because of the nature of the relationship between serum creatinine and creatinine clearance, rise in serum creatinine was divided by pretreatment creatinine squared.) Patients were dichotomized into the upper quartile versus the lower three quartiles of degree of nephrotoxicity.
Multivariate analyses were based on logistic regression, controlling for cisplatin dose per course.
Controlling for cisplatin dose per course, factors most closely associated with nephrotoxicity during the first course of cisplatin were : serum albumin and potassium, body surface area, and administration of cisplatin over 2-5 days per course vs 1 day (negative associations).
Controlling for cisplatin dose per course, the single factor most closely associated with maximum life-time cisplatin nephrotoxicity was concurrent use of vinca alkaloid (negative association). (...)
Mots-clés Pascal : Cisplatine, Toxicité, Rein, Chimiothérapie, Traitement, Anticancéreux, Tumeur maligne, Tumeur solide, Homme, Epidémiologie, Rétrospective, Association médicamenteuse, Ontario, Canada, Amérique du Nord, Amérique, Analyse multivariable, Platine II Complexe, Rein pathologie, Appareil urinaire pathologie
Mots-clés Pascal anglais : Cisplatin, Toxicity, Kidney, Chemotherapy, Treatment, Antineoplastic agent, Malignant tumor, Solid tumor, Human, Epidemiology, Retrospective, Drug combination, Ontario, Canada, North America, America, Multivariate analysis, Platinum II Complexes, Kidney disease, Urinary system disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0369454
Code Inist : 002B02U06. Création : 12/09/1997.