Hepatitis C virus infection and related liver disease in children of mothers with antibodies to the virus.
To evaluate the clinical, biochemical, and virologic features associated with hepatitis C virus (HCV) infection acquired early in life from mothers with antibodies to HCV (anti-HCV).
Multicenter prospective-retrospective study in Italian children.
Two groups of children were investigated.
Group 1 included 14 infants, born to mothers with anti-HCV but without human immunodeficiency virus infection, who became seropositive for HCV RNA during the first year of life and were thus considered infected.
Group 2 included 16 children with chronic hepatitis C, aged 1 1/2 to 14 years, whose mothers were the unique potential source of infection.
Both groups were followed for 12 to 48 months.
Alanine transaminase (ALT), anti-HCV, and HCV RNA were investigated by the polymerase chain reaction on entry to the study and during follow-up.
All children in group 1 had anti-HCV throughout follow-up, and all had ALT abnormalities, ranging from 1.5 to 10.5 times the normal value during the first 12 months.
During further follow-up, 5 of 10 children had HCV RNA with abnormal ALT values, 3 had a return to normal of the ALT values but continued to have viremia, and 2 eventually had normal ALT values and clearance of HCV RNA.
Of the 16 children in group 2, all were free of symptoms and 62% had only slight ALT elevations ; 7 who underwent liver biopsy had histologic features of minimal or moderate hepatitis. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Prévalence, Transmission mère enfant, Anticorps, Etude multicentrique, Exploration clinique, Immunochimie, Foie, Evaluation, Italien, Enfant, Homme, Italie, Europe, Appareil digestif pathologie, Foie pathologie, Pédiatrie, Immunopathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Prevalence, Mother to child transmission, Antibody, Multicenter study, Clinical investigation, Immunochemistry, Liver, Evaluation, Italian, Child, Human, Italy, Europe, Digestive diseases, Hepatic disease, Pediatrics, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0369224
Code Inist : 002B05C02G. Création : 12/09/1997.