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  1. A simplified schedule to integrate the hepatitis B vaccine into an expanded program of immunization in endemic countries.

    Article - En anglais

    Objective 

    To investigate the safety, immunogenicity, and efficacy of a simplified hepatitis B vaccination schedule.

    Methods 

    The second dose of hepatitis B vaccine and the first dose of diphtheriatetanus-pertussis (DTP) vaccine were given simultaneously at age 6 weeks.

    The second dose of DTP vaccine was given at age 3.5 months.

    The third dose of DTP vaccine and the third dose of hepatitis B vaccine were given at age 5.5 months.

    One hundred three infants (group A) born to mothers without hepatitis B surface antigen (HBsAg) received DTP with whole-cell pertussis vaccine.

    Fifty-five infants (group B) born to mothers with HBsAg and hepatitis B e antigen received DTP with acellular pertussis vaccine.

    Results 

    By age 9 months, none of group A and 4 (7%) group B infants were seropositive for HBsAg.

    The protective efficacy against the hepatitis B carrier state in these infants at high risk was 92%. Antibody to hepatitis B surface antigen was 10 mlU/ml or greater in 99 (96%) of group A infants and in 50 (91%) of group B infants.

    Both the acellular and whole-cell DTP vaccines were immunogenic, and the incidences of adverse reactions were within an expected and acceptable range.

    Conclusions 

    The simplified vaccination schedule to integrate the hepatitis B vaccine Into the Expanded Programme of Immunization was safe, immunogenic, and effective.

    This schedule may improve vaccine compliance and be applied to DTP and hepatitis B combination vaccines now under investigation.

    Mots-clés Pascal : Hépatite virale B, Virose, Infection, Vaccination, Epidémiologie, Méthode étude, Immunogénicité, Prévention, Critère âge, Programmation objectif, Indication, Enfant, Homme, Endémie, Appareil digestif pathologie, Foie pathologie, Immunoprophylaxie, Organisation santé

    Mots-clés Pascal anglais : Viral hepatitis B, Viral disease, Infection, Vaccination, Epidemiology, Investigation method, Immunogenicity, Prevention, Age criterion, Goal programming, Indication, Child, Human, Endemy, Digestive diseases, Hepatic disease, Immunoprophylaxis, Public health organization

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0369223

    Code Inist : 002B05A02. Création : 12/09/1997.