To evaluate the effect of viral load on the early growth of infants infected with human immunodeficiency virus (HIV).
Plasma concentrations of p24-antigen and HIV ribonucleic acid were measured retrospectively and correlated with growth parameters for the first 18 months of life in a cohort of 47 term infants born to HIV-infected mothers prospectively enrolled in a study of perinatal HIV transmission.
Comparisons of the mean weight and length of the 18 HIV-infected and 29 uninfected infants for each interval and across intervals were made.
Viral load was correlated with standard deviation scores.
Infants were stratified by high and low viral load during the first 6 months of life.
At birth, no difference in weight and length was observed between HIV-infected and uninfected infants.
Between birth and 6 months of age, the infected infants grew less rapidly than the uninfected infants, a finding temporally associated with an exponential increase in HIV viremia.
The linear growth of infected infants remained consistently less than that of the uninfected infants after 6 months of life, although the differences were no longer statistically significant and tended to decrease with age in parallel with declines in viral load.
The median plasma concentration of HIV ribonucleic acid was significantly higher at 3,6,12, and 18 months in infected infants in whom growth failure developed. (...)
Mots-clés Pascal : SIDA, Virose, Infection, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Incidence, Croissance, Périnatal, Etude comparative, Virémie, Charge, Transmission mère enfant, Evaluation, Poids corporel, Enfant, Homme, Immunopathologie, Immunodéficit, Pédiatrie, Métabolisme pathologie, Organisation santé
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Incidence, Growth, Perinatal, Comparative study, Viremia, Load, Mother to child transmission, Evaluation, Body weight, Child, Human, Immunopathology, Immune deficiency, Pediatrics, Metabolic diseases, Public health organization
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0369213
Code Inist : 002B06D01. Création : 12/09/1997.