In the past, special guidelines and protective measures have been introduced to protect hospital workers during the handling of antineoplastic agents ; nevertheless, it was found that they did not prevent the uptake of these toxic compounds.
In response, additional protective measures were introduced, including adaptations of the laminar downflow hood, use of special masks, use of double pairs of gloves, and replacement of ampules with vials.
In the current study, the authors compared the effects in these additional measures with results of a previous study.
Cyclophosphamide, 5-fluorouracil, and methotrexate constituted 81% of the antineoplastic agents prepared ; therefore, the investigators monitored these compounds again by personal air sampling and by determining the levels of contamination on masks and gloves.
Cyclophosphamide in the urine of workers was also measured.
During preparation, investigators concluded that there were lower concentrations of cyclophosphamide in the air than had occurred in the previous study.
Replacement of ampules with vials (i.e., 5-fluorouracil) resulted in a significantly diminished contamination of latex gloves.
Cyclophosphamide was detected in urine samples provided by six of nine technicians ; the maximum amount excreted over 5 d was 2.6 mug.
The mean cyclophosphamide excretion/d was not significantly lower than that found in the previous study (0.16 mug and 1.44 mug, respectively). (...)
Mots-clés Pascal : Anticancéreux, Toxicité, Personnel sanitaire, Préparation, Technicien, Laboratoire, Homme, Hôpital, Recommandation, Prévention, Travailleur(protection), Exposition professionnelle, Médecine travail, Evaluation, Pays Bas, Europe, Pharmacie hospitalière
Mots-clés Pascal anglais : Antineoplastic agent, Toxicity, Health staff, Preparation, Technician, Laboratory, Human, Hospital, Recommendation, Prevention, Worker(protection), Occupational exposure, Occupational medicine, Evaluation, Netherlands, Europe, Hospital pharmacy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0368660
Code Inist : 002B02U10. Création : 12/09/1997.