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  1. Treatment of shigellosis : V. Comparison of Azithromycin and ciprofloxacin a double-blind, Randomized, controlled trial.

    Article - En anglais

    Background 

    Treatment of shigellosis is currently limited by the high prevalence of multidrug-resistant strains of Shigella.

    Objective 

    To determine the efficacy of azithromycin in the treatment of shigellosis.

    Design 

    Randomized, double-blind clinical trial.

    Setting 

    Diarrhea treatment center in Dhaka, Bangladesh.

    Patients 

    70 men with shigellosis that had lasted 72 hours or less.

    Interventions 

    Patients stayed in the hospital for 6 days.

    Thirty-four patients were randomly assigned to receive 500 mg of azithromycin on study day 1, followed by 250 mg once daily for 4 days ; 36 patients were assigned to receive 500 mg of ciprofloxacin every 12 hours for 5 days.

    Measurements 

    Clinical treatment failure was considered to have occurred if frank dysentery persisted for 72 hours after therapy began or if on study day 5 a patient had more than six stools, had any bloody-mucoid stools, had more than one watery stool, or had an oral body temperature exceeding 37.8 °C. Bacteriologic treatment failure was considered to have occurred if Shigella strains could be isolated from a stool sample after study day 2. Therapy was considered either clinically or bacteriologically successful in patients who completed therapy and did not meet criteria for failure.

    Results 

    Therapy was clinically successful in 28 (82%) patients who received azithromycin and 32 (89%) patients who received ciprofloxacin (difference, - 7% [95% Cl, - 23% to 10% ]). (...)

    Mots-clés Pascal : Shigellose, Bactériose, Infection, Chimiothérapie, Etude double insu, Azithromycine, Etude comparative, Pharmacocinétique, Ciprofloxacine, Evaluation, Homme, Bengla Desh, Asie, Macrolide, Fluoroquinolone dérivé, Quinolone dérivé, Appareil digestif pathologie, Intestin pathologie, Organisation santé, Antibiotique, Antibactérien

    Mots-clés Pascal anglais : Shigellosis, Bacteriosis, Infection, Chemotherapy, Double blind study, Azithromycin, Comparative study, Pharmacokinetics, Ciprofloxacin, Evaluation, Human, Bangladesh, Asia, Macrolide, Fluoroquinolone derivatives, Quinolone derivatives, Digestive diseases, Intestinal disease, Public health organization, Antibiotic, Antibacterial agent

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0368260

    Code Inist : 002B02S02. Création : 12/09/1997.