The authors examined cancer mortality in a historical cohort study of 21,863 male and female workers in 36 cohorts exposed to phenoxy herbicides, chlorophenols, and dioxins in 12 countries.
Subjects in this updated and expanded multinational study coordinated by the Intemational Agency for Research on Cancer were followed from 1939 to 1992.
Exposure was reconstructed using job records, company exposure questionnaires, and serum and adipose tissue dioxin levels.
Among workers exposed to phenoxy herbicides contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or higher chlorinated dioxins, mortality from soft-tissue sarcoma (6 deaths ; standardized mortality ratio (SMR)=2.03,95% confidence interval (Cl) 0.75-4.43) was higher than expected from national mortality rates.
Mortality from all malignant neoplasms (710 deaths ; SMR=1.12,95% Cl 1.04-1.21), non-Hodgkin's lymphoma (24 deaths ; SMR=1.39,95% Cl 0.89-2.06), and lung cancer (225 deaths ; SMR=1.12,95% Cl 0.98-1.28) was slightly elevated.
Risks for all neoplasms, for sarcomas, and for lymphomas increased with time since first exposure.
In workers exposed to phenoxy herbicides with minimal or no contamination by TCDD and higher chlorinated dioxins, mortality from all neoplasms (398 deaths ; SMR=0.96,95% Cl 0.87-1.06), non-Hodgkin's lymphoma (9 deaths ; SMR=1.00), and lung cancer (148 deaths ; SMR=1.03) was similar to that expected, and mortality from soft-tissue sarcoma was slightly elevated (2 deaths ; SMR=1.35). (...)
Mots-clés Pascal : Pesticide, Herbicide, Phytohormone, Dibenzo-p-dioxine(polychloro), Phénol(polychloro), Carcinogène, Exposition professionnelle, Homme, Tumeur maligne, Mortalité, Epidémiologie, Toxicité, International, Médecine travail, Acétique acide(aryloxy)
Mots-clés Pascal anglais : Pesticides, Herbicide, Phytohormone, Carcinogen, Occupational exposure, Human, Malignant tumor, Mortality, Epidemiology, Toxicity, International, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0367758
Code Inist : 002B04B. Création : 12/09/1997.