Validation of pharmacy records in drug exposure assessment.
The validity of drug exposure measurement based on pharmacy records was investigated taking into account completeness of data, drug compliance, and different methods of drug exposure measurement in pharmacy records.
Data on prescription drug use were collected from home inventories and community pharmacies in a survey on drug use and compliance in 115 elderly people.
To compare drug exposure in pharmacy records with exposure in the home inventory, three different methods for exposure measurement in pharmacy records were used.
Two employed a fixed time window of 30 and 90 days, respectively, and the third method was based on the calculated duration of use of a prescription ( « legend time »). Drug exposure in the home inventory was taken as the gold standard and sensitivity, specificity, and positive predictive values of the different methods were calculated for the most frequently used drugs and drug categories.
The specificity and positive predictive value of all three methods was generally high (0.93-1.00 and 0.67-1.00, respectively).
The 90-day fixed method and the legend time method generally showed high sensitivity (range : 0.67-1.00 and 0.63-0.83, respectively) for drugs that were used on a chronic basis, while the 30-day fixed method had poor sensitivity (range : 0.29-0.69). (...)
Mots-clés Pascal : Epidémiologie, Médicament, Source information, Enregistrement, Prescription médicale, Vieillard, Homme, Validité, Pays Bas, Europe, Pharmacie officine
Mots-clés Pascal anglais : Epidemiology, Drug, Information source, Recording, Medical prescription, Elderly, Human, Validity, Netherlands, Europe, Pharmacy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0366015
Code Inist : 002B02A07. Création : 12/09/1997.