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  1. Hormone replacement therapy and major risk factors for reproductive cancers, osteoporosis, and cardiovascular diseases : Evidence of confounding by exposure characteristics.

    Article - En anglais

    Observational studies have yielded reports on long-term effects of hormone replacement therapy (HRT) for cardiovascular, osteoporosis-related, and cancer diseases.

    There is concern that risk estimates may be confounded by complex mechanisms of selection with regard to important risk determinants.

    In this study, we tested the hypothesis that baseline characteristics of women vary with exposure characteristics, i.e., the choices of complying wirh prescriptions, using different compounds and regimens, and continuing intake long-term.

    We analyzed the prevalence of relevant risk factors and their relationships to characteristics of exposure among 11,231 Swedish women who had received prescriptions for HRT.

    Associations were studied through logistic regression, with comparisons of women with ever-use versus non-compliance, long-term (73+months) versus short-term use (1-72 months), intake of conjugated estrogens versus estradiol compounds, and intake of estrogens only versus estrogens combined with progestins, respectively.

    We found that women denying intake or using HRT short-term had higher parity, earlier age at first birth and a lower prevalence of hysterectomy or oophorectomy than those complying or exposed long-term.

    A high level of education was associated with compliance and long-term exposure, and heavy physical exercise and high intake of food fibers were associated with compliance. (...)

    Mots-clés Pascal : Oestrogène, Hormone stéroïde sexuelle, Chimiothérapie, Traitement, Ménopause, Homme, Femelle, Prévention, Toxicité, Epidémiologie, Facteur risque, Suède, Europe, Facteur confusion

    Mots-clés Pascal anglais : Estrogen, Sex steroid hormone, Chemotherapy, Treatment, Menopause, Human, Female, Prevention, Toxicity, Epidemiology, Risk factor, Sweden, Europe

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0366014

    Code Inist : 002B02O. Création : 12/09/1997.