Prognostic value of clinical variables in ovarian cancer.
To test the hypothesis that clinical variables, including the patient's symptoms, symptom severity, and co-morbidity, affect the survival rate in patients with ovarian cancer.
We reviewed the records of 137 cases of ovarian cancer diagnosed and treated between January 1987 and June 1992, and extracted data regarding patients'demographic characteristics, symptoms, medical co-morhidity, stage of disease, tumor histology and grade, treatment, and clinical course.
Once cases of borderline tumors were excluded, the overall 3-year and 4-year mortality rate were 38% and 49%, respectively.
There was an decrease in 4-year survival with more advanced symptom type ranging from 85% in asymptomatic women to 38% in women with complex symptoms (log rank, p=0.005).
Medical co-morbidity was not found to affect survival in the cohort studied.
We performed multivariable analysis using a Cox proportional hazards model and confirmed that the symptom stage was highly prognostic even after controlling for FIGO stage, age, and co-morbidity (p=0.004).
We found that clinical variables, such as patient's symptoms, were associated with prognosis.
Symptom classification is a necessary and important component in a system of prognostic stratification for ovarian cancer.
Mots-clés Pascal : Tumeur maligne, Ovaire, Mortalité, Survie, Pronostic, Symptomatologie, Association morbide, Stade clinique, Indice gravité, Homme, Femelle, Rhode Island, Etats Unis, Amérique du Nord, Amérique, Epidémiologie, Appareil génital femelle pathologie, Ovaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Ovary, Mortality, Survival, Prognosis, Symptomatology, Concomitant disease, Clinical stage, Severity score, Human, Female, Rhode Island, United States, North America, America, Epidemiology, Female genital diseases, Ovarian diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0366003
Code Inist : 002B20C02. Création : 12/09/1997.