- To determine whether patients with classical polycystic ovarian syndrome (PCOS) respond differently to low-dose FSH therapy in comparison with anovulatory patients (PCOS-like) where only some features of PCOS are present.
Two groups of patients were studied.
The PCOS group (25 patients, 51 cycles) and the PCOS-like group (38 patients, 57 cycles) were treated with the same protocol of purified FSH, commencing with an initial dosage of 75 IU/day and increasing by 37.5 IU/day after 14 days, where necessary.
Estradiol levels and ultrasonographic evidence of follicular development were used for monitoring.
PCOS patients required more ampules of FSH, needed more days of gonadotropin stimulation, secreted higher levels of E2 and had increased numbers of intermediate follicles compared to the PCOS-like group.
This study demonstrated significant differences between PCOS and other PCOS-like conditions when treated with low-dose FSH.
Classification of the subvariants of PCOS may have therapeutic implications.
Mots-clés Pascal : Ovaire polykystique, Etude comparative, Traitement, FSH, Dose faible, Forme clinique, Cycle ovulatoire, Evaluation, Homme, Prévention, Femelle, Appareil génital femelle pathologie, Ovaire pathologie, Stérilité femelle, Tumeur bénigne, Kyste, Gonadotrophine, Hormone adénohypophysaire, Hormone glycoprotéine, Ovaire, Education santé
Mots-clés Pascal anglais : Polycystic ovary, Comparative study, Treatment, FSH, Low dose, Clinical form, Ovulatory cycle, Evaluation, Human, Prevention, Female, Female genital diseases, Ovarian diseases, Female sterility, Benign neoplasm, Cyst, Gonadotropin, Adenohypophyseal hormone, Glycoprotein hormone, Ovary, Health education
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0361242
Code Inist : 002B02P. Création : 12/09/1997.