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  1. Full-term birth weight and placental morphology at high and low altitude.

    Article - En anglais

    Objective 

    To study the association between placental morphology and full-term birth weight at high and low altitude.

    Subjects 

    Twenty normal pregnant women living permanently at high altitude (3100 m) and 20 normal pregnant women living permanently at low altitude (500 m) in Southern Saudi Arabia.

    Method 

    For each subject in the two groups the mean hemoglobin concentration and hematocrit values throughout pregnancy were estimated and these were used as indices for maternal hypoxia.

    After delivery, the birth weight of each fetus was determined together with the placental weight.

    Placentas were then examined histologically using sections stained by periodic acid-Schiff and hematoxylin-eosin.

    The mean percentages of villi with syncytial knots, cytotrophoblastic cells and fetal capillaries were determined.

    Results 

    The mean hemoglobin concentration and hematocrit values were significantly greater at high altitude than at low altitude (P<0.001 for both).

    The mean birth weight and placental weight were significantly greater at low altitude compared to high altitude (P<0.025 and 0.001, respectively).

    The placentas from high altitude showed histological changes suggestive of placental hypoxia i.e. significant increase in the incidence of syncytial knots, cytotrophoblastic cells and fetal capillaries at high altitude compared to low altitude (P<0.005,0.001 and<0.05, respectively). (...)

    Mots-clés Pascal : Poids naissance, Placenta, Association, Altitude, Etude comparative, Morphologie, Epidémiologie, Exploration clinique, Arabe, Hémoglobine, Arabie Saoudite, Asie, Evaluation, Femelle, Homme, Relation mère petit, Appareil génital femelle pathologie, Accouchement, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Organisation santé

    Mots-clés Pascal anglais : Birth weight, Placenta, Association, Altitude, Comparative study, Morphology, Epidemiology, Clinical investigation, Arabic, Hemoglobin, Saudi Arabia, Asia, Evaluation, Female, Human, Mother young relation, Female genital diseases, Delivery, Cardiovascular disease, Vascular disease, Public health organization

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0361236

    Code Inist : 002B20G01. Création : 12/09/1997.