- To examine the hypothesis that diverse ties to friends, family, work, and community are associated with increased host resistance to infection.
Design-After reporting the extent of participation in 12 types of social ties (eg, spouse, parent, friend, workmate, member of social group), subjects were given nasal drops containing 1 of 2 rhinoviruses and monitored for the development of a common cold.
Selling. - Quarantine.
Participants-A total of 276 healthy volunteers, aged 18 to 55 years, neither seropositive for human immunodeficiency virus nor pregnant.
Outcome Measures-Colds (illness in the presence of a verified infection), mucus production, mucociliary clearance function, and amount of viral replication.
- In response to both viruses, those with more types of social ties were less susceptible to common colds, produced less mucus, were more effective in ciliary clearance of their nasal passages, and shed less virus.
These relationships were unaltered by statistical controls for prechallenge virus-specific antibody, virus type, age, sex, season, body mass index, education, and race.
Susceptibility to colds decreased in a dose-response manner with increased diversity of the social network.
There was an adjusted relative risk of 4.2 comparing persons with fewest (1 to 3) to those with most (6 or more) types of social ties. (...)
Mots-clés Pascal : Refroidissement, Prédisposition, Incidence, Relation interpersonnelle, Multiple, Milieu familial, Milieu professionnel, Milieu culturel, Epidémiologie, Homme, Appareil respiratoire pathologie, Poumon pathologie, Infection
Mots-clés Pascal anglais : Cooling, Predisposition, Incidence, Interpersonal relation, Multiple, Family environment, Occupational environment, Cultural environment, Epidemiology, Human, Respiratory disease, Lung disease, Infection
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0361170
Code Inist : 002B30A01A2. Création : 12/09/1997.