The characteristics of patients suffering from drug resistant epilepsy, including the results of the preoperative evaluation and epilepsy surgery were retrospectively analyzed in a Swedish multicenter 10-year cohort of children and adults.
Altogether 152 patients (65 children and 87 adults) treated during the period 1980-1990 in three epilepsy centers were included and followed-up 2 years after surgery.
Median age at onset of seizures was 4 years for the children and 12 years for the adults.
A localization related epilepsy was present in 85% of the children and in 95% of the adults.
The mean number of seizure types in the children was 1.7 (range 1-4) and in the adults 1.8 (range 1-4).
The median monthly seizure frequency was 52 and 15 for children and adults respectively.
Resective surgery was performed in 143 cases (94 temporal, 31 extratemporal, 9 multilobar and 9 major resection procedures) and palliative procedures in 16 cases (13 callosotomies and 3 stereotactic amygdalotomies).
Postoperative neurological deficits were detected in 9% of the patients after temporal lobe resections and in 15% of the patients after extratemporal and multilobar resection procedures.
Two years after resective surgery 53% of the children and 49% of the adults were seizure free.
Another 25% of the patients had a more than 50% reduction of seizure frequency. (...)
Mots-clés Pascal : Epilepsie, Réfractaire, Suède, Europe, Etude multicentrique, Etude cohorte, Fréquence, Crise, Traitement, Evolution, Chirurgie, Enfant, Homme, Adulte, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Epidémiologie
Mots-clés Pascal anglais : Epilepsy, Refractory, Sweden, Europe, Multicenter study, Cohort study, Frequency, Crisis, Treatment, Evolution, Surgery, Child, Human, Adult, Nervous system diseases, Central nervous system disease, Cerebral disorder, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0360905
Code Inist : 002B25J01. Création : 12/09/1997.