The interrelationships between fibrinogen, von Willebrand factor, a marker of vascular endothelial cell damage, and serum lipids were explored in well-characterised subjects with insulin-dependent diabetes mellitus.
The 2091 subjects were enrolled into a cross-sectional, clinic-based study of complications, from 16 European countries : the EURODIAB IDDM Complications study.
The anticipated significant relationships between both plasma fibrinogen and plasma von Willebrand factor concentrations and age and glycaemic control, and between fibrinogen and body mass index, were noted.
Fibrinogen, adjusted for age and glycated haemoglobin concentration, was also related to smoking habits and was higher in the quartiles with highest systolic and diastolic blood pressures.
There was a clustering of vascular risk factors, with a positive relationship between plasma fibrinogen and serum triglyceride concentrations in both genders and between fibrinogen and total cholesterol in males.
An inverse relationship between fibrinogen and high density lipoprotein cholesterol was also apparent in males.
A prominent feature was a positive relationship between both fibrinogen and von Willebrand factor and albumin excretion rate (p<0.001 and p<0.003 respectively) in those with retinopathy but not in those without this complication. (...)
Mots-clés Pascal : Fibrinogène, Pression sanguine, Albumine, Facteur Willebrand, Vaisseau sanguin pathologie, Epidémiologie, Hémodynamique, Homme, Complication, Facteur risque, EURODIAB
Mots-clés Pascal anglais : Fibrinogen, Blood pressure, Albumin, Willebrand factor, Vascular disease, Epidemiology, Hemodynamics, Human, Complication, Risk factor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0355973
Code Inist : 002B21E01B. Création : 12/09/1997.