Seroprevalence and epidemiology of Helicobacter pylori infection in patients with cirrhosis.
Helicobacter pylori infection is the major pathogenic factor for peptic ulcer disease.
Its epidemiology is not fully known ; few data are available in patients with chronic liver disease.
To investigate the seroprevalence and factors associated with Helicobacter pylori infection in a series of liver cirrhosis patients.
Two hundred and twenty consecutive patients were prospectively included in a study aimed to evaluate the effect of dietary intervention on cirrhosis complications and survival.
At inclusion, an epidemiological and clinical questionnaire was completed.
Sera were obtained and stored at - 70°C until analyzed.
They were tested for Helicobacter pylori antibodies using a commercial ELISA kit.
Eleven out of 220 patients had borderline anti-Helicobacter pylori IgG titers.
Of the remaining 209 patients, 105 (50.2%) showed positive titers of Helicobacter pylori IgG.
Univariate analysis showed that Helicobacter pylori infection was more frequent in older patients, those born outside Catalonia, and in patients with a low educational level.
Past ethanol consumption and current smoking correlated negatively with Helicobacter pylori infection.
Multivariate analysis selected age (OR 3.1. 95% CI 1.46-6.45), educational level (OR 2.2. 95% CI 1.18-4.2) and alcohol consumption (OR 0.7. 95% CI 0.45-0.99) as the variables independently related to Helicobacter pylori infection. (...)
Mots-clés Pascal : Cirrhose, Epidémiologie, Prévalence, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Etiopathogénie, Facteur risque, Sérologie, Evaluation, Homme, Appareil digestif pathologie, Foie pathologie, Bactériose, Infection, Immunopathologie
Mots-clés Pascal anglais : Cirrhosis, Epidemiology, Prevalence, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Etiopathogenesis, Risk factor, Serology, Evaluation, Human, Digestive diseases, Hepatic disease, Bacteriosis, Infection, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0350889
Code Inist : 002B13C03. Création : 12/09/1997.