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  1. Seroprevalence and epidemiology of Helicobacter pylori infection in patients with cirrhosis.

    Article - En anglais

    Background 

    Helicobacter pylori infection is the major pathogenic factor for peptic ulcer disease.

    Its epidemiology is not fully known ; few data are available in patients with chronic liver disease.

    Aims 

    To investigate the seroprevalence and factors associated with Helicobacter pylori infection in a series of liver cirrhosis patients.

    Methods 

    Two hundred and twenty consecutive patients were prospectively included in a study aimed to evaluate the effect of dietary intervention on cirrhosis complications and survival.

    At inclusion, an epidemiological and clinical questionnaire was completed.

    Sera were obtained and stored at - 70°C until analyzed.

    They were tested for Helicobacter pylori antibodies using a commercial ELISA kit.

    Results 

    Eleven out of 220 patients had borderline anti-Helicobacter pylori IgG titers.

    Of the remaining 209 patients, 105 (50.2%) showed positive titers of Helicobacter pylori IgG.

    Univariate analysis showed that Helicobacter pylori infection was more frequent in older patients, those born outside Catalonia, and in patients with a low educational level.

    Past ethanol consumption and current smoking correlated negatively with Helicobacter pylori infection.

    Multivariate analysis selected age (OR 3.1. 95% CI 1.46-6.45), educational level (OR 2.2. 95% CI 1.18-4.2) and alcohol consumption (OR 0.7. 95% CI 0.45-0.99) as the variables independently related to Helicobacter pylori infection. (...)

    Mots-clés Pascal : Cirrhose, Epidémiologie, Prévalence, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Etiopathogénie, Facteur risque, Sérologie, Evaluation, Homme, Appareil digestif pathologie, Foie pathologie, Bactériose, Infection, Immunopathologie

    Mots-clés Pascal anglais : Cirrhosis, Epidemiology, Prevalence, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Etiopathogenesis, Risk factor, Serology, Evaluation, Human, Digestive diseases, Hepatic disease, Bacteriosis, Infection, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0350889

    Code Inist : 002B13C03. Création : 12/09/1997.