To evaluate the clinical, biochemical and histological implications of a concomitant HGV infection in « HCV-related » chronic liver disease.
Eighty-three HCV-RNA positive patients with chronic liver disease were tested for GBV-C/HGV coinfection by heminested PCR.
Twenty-two (26.5%) patients were found to be positive for GBV-C/HGV RNA.
GBV-C/HGV+patients differed significantly from GBV-C/HGV-ones for younger age, higher frequency of history of drug addiction, which in turn might favor coinfection with interferon-sensitive HCV genotypes (3a), and increased probability of long-term response to interferon.
GBV-C/HGV infection appears to have no responsibility for specific aspects of HCV infection such as biochemical or histological cholestatic features, lymphoid follicles, symptomatic cryoglobulinemia or presence of serum autoantibodies, including LKM1 It does not worsen the HCV-related disease (ALT levels and histological activity) and does not significantly interfere with HCV infection, as explored by the number of hepatocytes positive for HCV antigens.
The amount of steatosis (mean score) was shown to be higher in GBV-C/HGV+patients.
A virological follow up was performed in 17 interferon-treated GBV-C/HGV+patients On the whole, GBV-C/HGV seems to be as sensitive to IFN treatment as HCV, but recurrence after withdrawal is more frequent.
In spite of this, ALT levels often remain normal after treatment withdrawal. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Complication, Evaluation, Analyse biochimique, Exploration clinique, Histopathologie, Association morbide, RNA, Forme clinique, Homme, Appareil digestif pathologie, Foie pathologie, Activité biologique, GBV-C/HGV infection
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Complication, Evaluation, Biochemical analysis, Clinical investigation, Histopathology, Concomitant disease, RNA, Clinical form, Human, Digestive diseases, Hepatic disease, Biological activity
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0350878
Code Inist : 002B05C02G. Création : 12/09/1997.